Question

A mutation in human ATPase 6 (which corresponds to E. coli subunit a) from leucine to arginine at position 156 may allow the movement of protons across the membrane, but not the rotation of the ring of c subunits. How might this possible mechanism affect the function of ATP synthase? Choose two answers.
1. There would be an uncoupling of proton translocation and ATP synthesis.
2. ATP hydrolysis coupled to proton transport out of the matrix would increase.
3. There would be no net effect on the overall function of ATP synthase.
4. ATP synthase would remain sensitive to F0 proton conduction inhibitors.
5. The c subunits would not fold correctly.
6. Proton binding to subunit c would be impaired.

Answer 1

A protein called ATP synthase uses inorganic phosphate and adenosine diphosphate (ADP) to produce the energy storage molecule adenosine triphosphate (ATP) (Pi). It is classified as a ligase because it forms a P-O connection to modify ADP (phosphodiester bond).

an ATP synthase, a type of molecular machine. Energy-wise, it is preferable for the process to proceed in the other ligase  direction rather than producing ATP from ADP and Pi. This process is propelled forward by a proton (H+) concentration gradient across the ligase inner mitochondrial membrane in eukaryotes or the plasma membrane in bacteria. The gradient is coupled to ATP generation during cellular respiration.

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