There is an alteration in distribution of charges.
The second channel opens as a result of changes in the distribution of charges close to the first channel brought on by the movement of many ions (both inside and outside the cell).
A membrane's voltage varies rapidly in a series known as action potentials. The relative ratio of extracellular to intracellular ions and the permeability of each ion define the membrane voltage, or potential, at any given time.
Depolarization, a sudden rise in potential, occurs all-or-nothing in neurons and is brought on by the opening of sodium ion channels in the plasma membrane.
Repolarization, the ensuing restoration to the resting potential, is mediated by the opening of potassium ion channels. An ATP-driven pump (Na/K-ATPase) induces movement of sodium ions out of the cell and potassium ions into the cell to restore the proper balance of ions.
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