Question

if malaria was somehow wiped out in western africa, what genotype would eventually become most fit? let s represent the sickle cell allele and a rpresent the normal allele.

Answer 1

Sickle cell trait (genotype HbAS) offers a high level of resistance to difficult and severe malaria [1-4], however, the exact mechanism is yet understood.

Because it is partially protected from anemia and malaria, genotype AS has the highest fitness of the three. Because the loss of S alleles from anemia is balanced off by the loss of A alleles from malaria, both alleles are kept in a state of balanced polymorphism.

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