Two groups are retrospectively identified and "prospectively" compared in retrospective cohort studies using the following model: from a cohort of healthy subjects: one group is exposed to a certain factor, and other is not.
In a retrospective, cohort analysis, triptorelin and leuprolide, two distinct GnRH agonists, were evaluated for their effectiveness in final oocyte prospectively maturation in individuals at higher risk for ovarian hyperstimulation cohort syndrome (OHSS). Leuprolide and triptorelin therapy groups each experienced one mild occurrence of OHSS, with both patients expressing complaints of lower abdomen pain, slight nausea, enlarging of the ovaries, and vomiting.
Both patients were under 25 years old, had increased estrogen levels prospectively greater than 4000 pg/mL, and had more than 25 oocytes harvested. In cohort terms of clinical pregnancy and OHSS rates versus placebo, both drugs were comparable [14c].
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