mRNA binding to ribosomes is most likely impaired in the patients with hereditary anemia with mutation in Beta globin gene which results in replacement of Guanine(G) by Cytosine(C) in the B globin chain mRNA molecule 3 bases upstream from AUG codon.
Mutations in the beta globin gene are responsible for a number of inherited blood disorders. Most people with a mutation in the beta globin gene have no symptoms, but some develop disorders such as sickle-cell anemia and thalassemia. Sickle-cell anemia is characterized by the production of abnormal hemoglobin molecules that become inflexible at low temperatures. In individuals with sickle cell anemia, these abnormal hemoglobin molecules can block small blood vessels and cause severe damage to the kidneys, lungs, and heart. Individuals with thalassemia exhibit reduced production of normal hemoglobin and other abnormal forms of hemoglobin called delta and alpha globin chains.
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