Pathogenic microbes get around this limitation by producing their own iron binding molecules known as siderophores Stripping the iron bound to lactoferrin/transferrin molecules.
Lactoferrin (LF), also known as lactotransferrin (LTF), is a transferrin family protein with multiple functions. Lactoferrin is a globular glycoprotein with an approximate molecular mass of 80 kDa that is found in a variety of secretory fluids including milk, saliva, tears, and nasal secretions. Lactoferrin increases iron uptake by intestinal cells by entering the cell via its own receptor. Iron is then set to release from lactoferrin within the intestinal cell and translocated to the bloodstream via transferrin.
A pathogenic organism is one that is responsible for the disease in its host (person). The World Health Organization (WHO) identified harmful organisms, viruses, toxins, parasites, and chemicals as potential hazards in food. Pathogens are classified into bacteria, viruses, fungi, and parasites. They can be found in almost every environment on the planet, and the bacteria carried by the average human, primarily in the gut, outnumber human cells.
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