Respuesta :
Primordial germ cells in zebrafish follow a migratory path that is directed by SDF-1 and CXCR4.
In zebrafish, primordial germ cells migrate along a path directed by SDF-1.
SDF-1 is another name for stromal cell-derived factor-1. It also promotes the mobilization and migration of hematopoietic cells in many mammals. However, in the zebrafish, SDF-1 guides primordial germ cell migration, which results in the formation of bleb-like protrusions via cytoplasmic flow.
The axis is linked to MSC migration and homing in vivo. MSCs transplanted into the body migrate to wounded tissues and focus on promoting tissue regeneration. SDF-1 regulates repair activity as well as the migration and homing of CXCR4-positive MSCs to damaged tissues.
Primordial germ cells are particularly specialized cells that serve as the progenitor cells for gametes, which progress after meiosis as haploid sperm and eggs that fertilize to produce new organisms.
They pass on genetic and epigenetic data from generation to generation, ensuring species survival.
In mammals, it is induced by BMP signals from the surrounding tissue in a subset of cells in the peri-implant epiblast.
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