gene transcription rates and mrna levels were determined for an enzyme that is induced by glucocorticoids. compared with untreated levels, glucocorticoid treatment caused a 10-fold increase in the gene transcription rate and a 20-fold increase in both mrna levels and enzyme activity. these data indicate that a primary effect of glucocorticoid treatment is to decrease which one of the following? (A) The activity of RNA polymerase II
(B) The rate of mRNA translation
(c) The ability of nucleases to act on mRNA
(d) The rate of binding of ribosomes to mRNA
(E) The rate of transcription initiation by RNA polymerase II

Pharmacological doses of glucocorticoids are used to treat patients with inflammatory, allergic, and immune disorders
Glucocorticoids regulate the inflammatory response by suppressing the expression of proinflammatory cytokines by immune cells.
In addition, glucocorticoids can suppress the expression of adhesion molecules that prevent neutrophil unwinding, adhesion, and extravasation at sites of inflammation.
In contrast, anti-inflammatory mediators are often upregulated by glucocorticoids.
Examples of glucocorticoid drugs are: beclomethasone, betamethasone, dexamethasone, budesonide, cortisone, hydrocortisone, prednisolone and methylprednisolone etc.

What organs do glucocorticoids affect?

Glucocorticoids affect gonadal function at several levels of the hypothalamic-pituitary-gonadal axis: 1) hypothalamus (to decrease GnRH synthesis and release); 2) pituitary (to inhibit LH and FSH synthesis and release); 3) testis/ovary (to regulate steroidogenesis and/or gametogenesis).

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