Question

Parkinson disease (PD) is a neurodegenerative disease that has been associated with a significant number of different genes, therefore showing it to be genetically heterogenic. One recent study in 278 families found evidence of two such possible loci. Evidence for linkage to chromosome 18q11 was presented by Gao et al. in 2009. Which of the following would be considered reputable evidence for this?
analysis of all other possible SNPs with no such association to chromosome 18
finding the locus to be in Hardy-Weinberg equilibrium in the population
finding the Lod score for association between the chromosomal location and PD to be 4.1
use of persons from multiple ethnic and geographic backgrounds in the study
lack of quantitative difference for the occurrence of both in individuals

Answer 1

The correct answer D) finding the Lod score for association between the chromosomal location and PD to be 4.1.

Parkinson's disease is a progressive neurological disorder that affects the nervous system and nerve-controlled parts of the body. The symptoms emerge in stages. A slight tremor in only one hand could be the first symptom. Tremors are common, but the disorder can also cause stiffness or slow movement.

In the early stages of Parkinson's disease, your face may be expressionless. When you walk, your arms may not swing. Your speech may become slurred or soft. Parkinson's disease symptoms worsen as the disease progresses.

Although Parkinson's disease cannot be cured, medications can help you feel better. Occasionally, your doctor may recommend surgery to control certain areas of your brain and alleviate your symptoms.

Learn more about Parkinson's disease to visit this link

https://brainly.com/question/26431892

#SPJ4

Full question

Parkinson disease (PD) is a neurodegenerative disease that has been associated with a significant number of different genes, therefore showing it to be genetically heterogenic. One recent study in 278 families found evidence of two such possible loci. Evidence for linkage to chromosome 18q11 was presented by Gao et al. in 2009. Which of the following would be considered reputable evidence for this?

A) lack of quantitative difference for the occurrence of both in individuals

B) use of persons from multiple ethnic and geographic backgrounds in the study

C) finding the locus to be in Hardy-Weinberg equilibrium in the population

D) finding the Lod score for association between the chromosomal location and PD to be 4.1

E) analysis of all other possible SNPs with no such association to chromosome 18