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The likelihood that their subsequent child will be born with alkaptonuria is 1/4 if the ailment is genetic like the majority of human diseases.
Only three-fourths of the F2 exhibited the dominant phenotype, compared to 100% of the F1.
Tyrosine and phenylalanine are two of the amino acids that make up proteins, and alkaptonuria, often known as black urine sickness, is a relatively rare genetic disease that inhibits the body from completely metabolizing these amino acids. It causes the body to accumulate homogentisic acid, a chemical. This can eventually cause a variety of health issues and render the urine and other bodily fluids a dark color. Chemical processes are typically used to break down amino acids. However, homogentisic acid, a chemical created along the way, cannot be further decomposed in alkaptonuria. This is due to improper operation of the enzyme that usually breaks it down. Proteins called enzymes are responsible for causing chemical reactions. Darkly stained diapers are one of the condition's early warning signs since homogentisic acid turns urine black when it's exposed to air for a few hours. The illness might not be recognized until maturity if this symptom is missed or disregarded in a baby or kid because there are typically no other obvious symptoms until the person is in their late twenties and early thirties.
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