Summary. Leukocytes cross the endothelial vessel wall in a process called transendothelial migration (TEM).
The purpose of leukocyte TEM is to remove inflammation-causing agents in the underlying tissues, for example, bacteria and viruses. Neutrophils comprise 50% to 70% of circulating leukocytes and represent the body's initial line of defense. They are involved in the acute inflammatory response to bacterial infection and the elimination of bacteria by phagocytosis. They are also the most numerous cells to reach the site of injury or infection. The function of inflammation is to remove the initial cause of cell injury, remove necrotic cells and tissues damaged by the original injury and the inflammatory process, and initiate tissue repair. activated neutrophils secrete a variety of proinflammatory cytokines and express MHC Class II (MHCII) in a manner that allows for antigen presentation and T cell activation. Resolution of termination, scarring, or chronic inflammation.
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