Question

consider the following dna sequence, which codes for the first portion of a long protein beginning at the atg (aug in mrna) start codon. 5' atg ccc cgc agt agg ggg tgg aga3' a mutation occurs changing this sequence to: 5' atg ccg cgc agt agg ggg tgg aga3' what type of mutation is this? (check all that apply.)

Answer 1

5' ATG CCC CGC AGT AGG GGG TGA AGA3' sequence is likely to be a deleterious mutation.

Explaination:

A missense mutation that converts a glycine to glutamic acid is seen in the sequence 5' ATG CCC CGC AGT AGG GAG TGG AGA 3'. A premature stop codon is introduced in the 7th codon due to a nonsense mutation in the sequence 5' ATG CCC CGC AGT AGG GGG TGA AGA 3'. The amino acid is unaffected by a silent mutation in the second codon of the sequence 5' ATG CCG CGC AGT AGG GGG TGG AGA 3'. Because the truncated protein is unlikely to be able to perform its intended function, the nonsense mutation, which causes a premature stop codon in the 7th codon, is most likely to be harmful to the cell.

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