The client on sulfonamide therapy for the past 6 weeks reports including 10 lb weight loss might prompt healthcare providers to stop using sulfonamides.
What kind of antibiotic is a sulfonamide?
- Sulfonamides, or sulfa drugs, are a class of broad-spectrum antibiotics that act against a wide range of Gram-positive and Gram-negative bacteria.
- Rather than killing bacteria, sulfa drugs stop the infection by inhibiting their growth and reproduction.
- Sulfa drugs or "sulfonamides" are used to treat urinary tract infections (UTIs). inflammatory bowel disease; malaria; skin, vaginal and eye infections; burns; and other conditions.
- Sulfonamides work by inhibiting dihydropteroate synthase (DHPS) enzyme.
What are the effects of sulfonamides?
Sulfonamides inhibit bacterial growth by acting as competitive inhibitors of p-aminobenzoic acid in the folate metabolic cycle. Bacterial susceptibility is the same for different sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally.
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