Disulfiram prevents this oxidation by blocking ALDH, which causes a sharp increase in acetaldehyde levels in the blood. The outcome is known as a disulfiram-alcohol reaction, and it can raise the blood's acetaldehyde levels by a factor of 5 to 10.
Disulfiram permanently inhibits aldehyde dehydrogenase by interacting with nicotinamide adenine dinucleotide (NAD) at the cysteine residue in the active region of the enzyme. The liver enzyme ALDH1A1 is used in the primary oxidative pathway of alcohol metabolism to change acetaldehyde into acetate.
Abstract. The only medication currently on the market used in the aversion therapy of recovering alcoholics is disulfiram (DSF). It works by preventing aldehyde dehydrogenase (ALDH), which raises acetaldehyde levels in the blood.
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