Question

Identify the statements that accurately describe the structure of the pyruvate dehydrogenase (PDH) complex. Select all that apply.
a. The core of the complex is made up of several copies of E2.
b. E2 contains three functionally distinct domains.
c. Several copies each of E1 and E3 surround E2.
d. A regulatory kinase and phosphatase are part of the mammalian PDH complex.
e. The complex contains multiple copies of E2 and single copies of several other enzymes.

Answer 1

Option a, b, c & d are the statements that accurately describe the structure of the pyruvate dehydrogenase (PDH) complex. Regulation arises from activation and deactivation.

The pyruvate dehydrogenase (PDH) complex in eukaryotes is tightly controlled by the enzymes pyruvate dehydrogenase kinase (PDK) and pyruvate dehydrogenase phosphatase (PDP).

Multiple copies of the pyruvate dehydrogenase (E1) and the di-hydrolipoyl dehydrogenase (E3) in eukaryotes bind exclusively to the surface of the complex E2's core (dihydrolipoyl transacetylase).

The multidomain structure of dihydrolipoyl transacetylases complex is unique and consists of three lipoyl domains, an interaction domain, and a catalytic domain. The form of the arrangement of dihydrolipoyl transacetylase enzymes might be cubic or dodecahedral.

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