Pyruvate carboxylase and phosphoenolpyruvate carboxykinase catalyze gluconeogenesis that bypasses the glycolysis reaction catalyzed by pyruvate kinase.
The tissues of some organs such as the brain, eyes, and kidneys use glucose as their primary or sole source of metabolic fuel. Glycogen stores are depleted during prolonged high-speed or strenuous exercise, and glucose must be made from scratch to keep blood sugar levels stable.Non-hexose precursors such as glycerol, lactate, pyruvate, and glycogenic amino acids The process by which glucose is produced by the body is known as gluconeogenesis.
Glycolysis is effectively reversed during glucose synthesis. However, using four different enzymes in gluconeogenesis, he skips three highly exergonic (and essentially irreversible) steps of glycolysis. The enzymes pyruvate carboxylase, PEP carboxykinase, fructose-1,6-bisphosphatase, and glucose-6-phosphatase are specific for gluconeogenesis. Since these enzymes are not found in all cell types, gluconeogenesis occurs only in specific tissues. In humans, the major sites of gluconeogenesis are the liver and, to a lesser extent, the renal cortex.
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Pyruvate carboxylase and phosphoenolpyruvate carboxykinase catalyze reactions of gluconeogenesis that bypass the reaction of glycolysis that is catalyzed by?
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