The key difference between thrift genotype hypothesis and the thrifty phenotype hypothesis is when specific populations have genes that were historically beneficial, that enable efficient storage of fat during times of food scarcity or in feast to compensate for times of famine.
Thrifty phenotype hypothesis states that the epidemiological associations occurs between poor fetal and infant growth and the consequent development of type 2 diabetes and many disease result from the cause of poor nutrition in early life, that produces long lasting changes in glucose-insulin metabolism.
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