Cell-cycle checkpoints prevent the transmission of genetic errors to daughter cells. There exist three major cell-cycle checkpoints; the G1/S checkpoint, the G2/M checkpoint, and the spindle assembly checkpoint (SAC).
The vast amount of DNA contained within the chromosomes must be precisely duplicated before being precisely separated into two daughter cells that are genetically identical. This is the most fundamental task of the cell cycle.
Walther Flemming was the first to depict the various steps in the cell cycle that lead to cell division in 1882 after creating techniques to stain cells that revealed subcellular structures. To divide the genetic material in a cell, spindle fibers create a protein structure. When a parental cell undergoes mitosis or meiosis, the spindle is required to divide the chromosomes into two daughter cells in an equal number. The spindle fibers that form the mitotic spindle are known as such during mitosis.
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