If you added a drug to cells that blocked the site on wee1 which gets phosphorylated then CAK activity would be necessary for cell cycle progression and M-CDK-cyclin activity would be lower than in normal cells.
Wee1 is a nuclear protein which is involved in the regulation of the G2/M checkpoint by negatively regulating entry in the mitosis by catalyzing inhibitory tyrosine phosphorylation of the Cdc2/cyclin B kinase complex.
The Cyclin dependent kinases are the main cell cycle drivers, but their activities must be fine-tuned to ensure orderly cell cycle progression. A major regulatory axis is guarded by WEE1 kinase, that directly phosphorylates and inhibits CDK1 and CDK2.
To know more about phosphorylated, refer
https://brainly.com/question/28104029
#SPJ4
