Follicular dendritic cells (FDCs) are a specialized type of antigen-presenting dendritic cells that are largely restricted to lymphoid follicles. They capture immune complexes either directly from the lymph or from macrophages and move to the lymphoid tissue, where they transfer complement opsonized antigen to the FDCs.
Follicular dendritic cells in turn attract B cells and activate them. They form dense three-dimensional meshwork patterns within benign follicles, which maintain the follicular architecture.
Follicular dendritic cells take part in B-cell activation and play an important role during affinity maturation by displaying native antigens and by presenting survival signals to B cells and that they are involved in memory B-cell development.
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