Heme, the component of hemoglobin, is made possible by folic acid. Folic acid supplementation has no effect on sickling or the risk of vaso-occlusive crises.
Vaso-occlusive crises can be avoided by getting enough oxygen and water. Although it can increase oxygen supply by producing hemoglobin, it does not lessen the need for cellular oxygenation.
A paradoxical drop in DO2 and iatrogenic hemodilution may result from the administration of large volumes of intravenous fluids. Blood transfusions may be necessary but not necessary if the associated decrease in Hb values falls below the acceptable transfusion threshold.
Red blood cell removal with the purpose of lowering hematocrit is known as hemodilution. The obvious outcome of this is that, if necessary, the red cells can be replaced in the future.
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