what type of mutation in a defective retrotransposon that cannot move on its own could allow its mobilization in the presence of a wild-type copy of the retrotransposon that can move on its own? in other words, which function, disrupted by mutation, can be provided by a non-defective copy of the retrotransposon elsewhere in the genome for transposition to occur?

A type of mutation in self-propelled wild-type retrotransposons is a promoter of the retrotransposon is deleted so the RNA intermediate cannot be made. In other words, one of the long terminal repeats is deleted.

What are retrotransposons?

Retrotransposons are also called class I transposons which can be described as copy and paste. The retrotransposon copies itself in two stages, first from DNA to RNA by transcription. Then, from RNA back to DNA by reverse transcription. This DNA copy is then inserted into the genome at a new position. Reverse transcription is catalyzed by the enzyme transcriptase which is often encoded by the transposon itself.

Retrotransposons can undergo transposition by carrying out a reverse transcription process to convert genetic elements in the form of RNA into DNA. This process is catalyzed by the enzyme reverse transcriptase. After the DNA is formed, it is inserted into the target side. Some genetic elements transposed in this way are related to retroviruses, so such transposons are often called retrovirus-like elements.

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