Nmda receptors include metabotropic receptors, which are a subclass of membrane receptors that use signal transduction processes instead of forming an ion channel pore.
Metabotropic receptors are really a subclass of membrane receptors which do not create an ion channel pore but instead use signaling molecules mechanisms, frequently G proteins, to trigger a cascade of intracellular actions via second messenger chemicals.
When a neurotransmitter binds to a metabotropic receptor, G-proteins are activated. After the receptor is released, the G-protein interacts with ion channels directly or binds to other effector proteins, including such enzymes, to produce intracellular messengers that opens and closes ion channels.
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