The mutation of K-ras and TP53 gene occurs in cancers of the stomach, colon, liver, gallbladder, and pancreas.
What is K-ras and TP53 ?
- Stomach-Non-environmental risk factors include pernicious anaemia, family history, blood type, and type A atrophic gastritis. Food additives in pickled or salted foods, H. pylori infection, salt added to foods, H. pylori infection carrying the CagA gene product cytoxin associated antigen A, and limited intake of fruits and vegetables are the main risk factors.
- Environmental and colon-genetic factors are linked to the emergence of CRC. 75–85% of patients have alterations in the tumor-suppressor TP53 gene. genetic changes affecting TP53 and DCC.
- fifth most common cancer is liver. third most common cause of death in the globe. Hep B and C infection rose as d/t increased. Metastatic spread is the usual culprit.
- The mutation of K-ras and TP53 gene occurs in cancers of the stomach, colon, liver, gallbladder, and pancreas.
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