In the 1940’s, some physicians prescribed low doses of a drug called dinitrophenol (DNP) to help patients lose weight. This unsafe method was abandoned after a few patients died. DNP causes the inner mitochondrial membrane to become leaky to H+ ions, allowing H+ in/out of the matrix. a) Explain how this affects chemiosmosis. b) Explain how this could help a person lose weight, and possibly lead to death.

Respuesta :

Chemiosmosis depends on the gradient between low H+ ions concentration inside the mitochondiral membrane/ high H+ ions concentration outside the mitochondrial memrabane. The mitochondria's membrane divides a gradiente of H+ ions. Outside the membrane there is high concentration of H + ions, while inside there are few H+ ions. Since there are a lot of H+ ions outside the membrane, when they entered the mitochondria they entered with high kinetical energy. They entered through special channels, that use this kinetic energy to produce high energy molecules, such as ATP. ----///---- For letter b), since less ATP is made with the same amount of "fuel" (carbohydrates or lipids), then the cell needs to burn more to fulfill it's energetic needs. DNP impairs chemiosmosis, therefore it would decrease efficiency in mitochondria energy production, so the cells will need to burn more calories to reach the same energetic budget, eventually it will start to burn fats and weight will go down. If this tendency continues, death may follow after insufficiente energy for the cells requirements and overheat.