How do I solve this in the easiest and simplest way possible? Please explain step by step as I am new to this

Use the next property for negative exponents:
[tex]a^{-n}=\frac{1}{a^n}[/tex][tex]2^{-2}=\frac{1}{2^2}=\frac{1}{2\times2}=\frac{1}{4}[/tex]