We have to determine the 3% per year first, and then multiply it by 25 (The total ammount of years):
[tex]x=\frac{375000\cdot3}{100}\Rightarrow x=11250[/tex]So $11250 is the yearly interest, and now for 25 years it would be:
[tex]T=11250\cdot25\Rightarrow T=281250[/tex]So, in 25 years you would need to pay $281250 on interest.