Question

Histamine binds to the h1 g-protein-linked receptor to initiate the itchiness and airway constriction associated with an allergic response. If a mutation in the associated g-protein’s alpha subunit prevented the hydrolysis of gtp how would the allergic response change?.

Answer 1

To initiate allergic signals such as itchiness, histamine needs to bind to the h1 G-protein-linked receptor. If a mutation in the associated G-protein’s alpha subunit prevented the hydrolysis of GTP, the allergic response would change: to be more severe compared to the normal G-protein signaling.

What happens when G-protein mutated?

G-proteins or guanine nucleotide-binding proteins are responsible to transmit signals from stimuli outside a cell to its interior. It becomes clear if G-proteins mutated, this function would no longer work properly. Mutations either lead to loss or gain of function by inactivating or activating signal transduction. In allergic cases, we might experience a more severe allergic response because of the mutation.

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