The pharmacology instructor is discussing heparin with their students. How would the instructor explain the action of heparin?

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26-10-2022
Medicine

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The pharmacology instructor is discussing heparin with their students. How would the instructor explain the action of heparin?

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Qwlizard Qwlizard · Answer 1 · 2022-10-27T18:48:19+02:00

In order to explain how heparin works, the instructor will promote the inactivation of clotting factors.

Heparin prevents prothrombin from forming thrombin. Factors X and Xa do not bind to heparin. Factor VIII is not rendered inactive by heparin.

A drug and naturally occurring glycosaminoglycan, heparin are also known as unfractionated heparin (UFH). Heparin is a naturally occurring compound that stops clots from forming and spreading. In contrast to warfarin, which is typically used for long-term treatment, heparin is used to offer a rapid reaction. Within 20 to 60 minutes of administration, heparin begins to function in your body, and its effects persist for 8 to 12 hours.

Hemodialysis uses unfractionated heparin. Unfractionated heparin is less expensive and does not have a lasting anticoagulant effect following dialysis compared to low-molecular-weight heparin. Heparin, however, needs to be continuously infused in order to sustain its activity due to its short half-life.

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