Active transport into surrounding cells can lead to termination of neurotransmitter activity.
Neurotransmitters are released into the synapses to forward the signals to the receptors of the postsynaptic neurons. These neurotransmitters need to be cleared off to forward new signals. Three mechanisms can be followed to terminate these neurotransmitters in order to introduce new neurotransmitters: diffusion, degradation, and reuptake.
Diffusion
Neurotransmitters in the synapses move until the concentrations are equal. Example- Nitric oxide
Degradation
Neurotransmitters can be broken down by the action of enzymes in order to clear off the synapses. Example- Acetylcholine
Reuptake
Neurotransmitters can also be recycled. In this mechanism, the presynaptic neuron introduces a protein into the synapse that pushes the neurotransmitters against the concentration gradient to push it out of the cell membrane. Examples include glutamate.
Therefore, in the autonomic nervous system, neurotransmitter activation of its receptors terminates when the neurotransmitter is broken down by enzymes, or when it diffuses away, or when it is pushed against the concentration gradient through active transport.
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