The primary signal in the stomach lumen that results in inhibition of gastrin secretion exist somatostatin.
Somatostatin is a hormone that controls a number of body processes by preventing the release of other hormones, gastrointestinal tract activity, and cell division at a high rate.
Growth hormone-inhibiting hormone (GHIH), also referred to as somatostatin or by a number of other names, is a peptide hormone that regulates the endocrine system and influences neurotransmission and cell proliferation through interactions with G protein-coupled somatostatin receptors and the inhibition of the release of numerous secondary hormones. Somatostatin prevents the release of glucagon and insulin.
A single preproprotein is split into two active forms of somatostatin, one with 14 amino acids (as indicated in the infobox to the right) and the other with 28 amino acids.
Hence, The primary signal in the stomach lumen that results in inhibition of gastrin secretion exist somatostatin.
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