When an antigen is bound to a class i mhc molecule, it can stimulate a cytotoxic T cell
A transmembrane chain, which is produced by a class I MHC gene, plus a tiny extracellular protein known as 2-microglobulin make up class I MHC proteins. The gene that encodes the 2-microglobulin does not belong to the MHC gene cluster, and it does not traverse the membrane.
The cytotoxic T cell interacts with a virally infected cell via its T cell receptor and the MHC class one protein on the virally infected cell, which is the interaction between the MHC class one protein and the cytotoxic T cell. The identification of targets for destruction by a cytotoxic T cell depends on this interaction between the T cell receptor and MHC class one.
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