The echinocandin drugs anidulafungin (ANF), caspofungin (CSF) and micafungin (MCF) were the first members of the lipopeptide class of antifungal drugs.
A molecule called a lipopeptide is made up of a lipid and a peptide. They may put themselves together to form various structures. Numerous bacteria, particularly those belonging to the genera Bacillus, Pseudomonas, and Streptomyces, generated these compounds as part of their metabolism.
Antibiotics are made from some lipopeptides. Agonists of toll-like receptors are other lipopeptides. Some lipopeptides have potent hemolytic and antifungal properties.
It has been shown that interactions with the plasma membrane are generally linked to their activity, and the plasma membrane's sterol components may play a significant role in this interaction.
Amphiphiles and two alkyl chains, which are present on the final segment of the peptide backbone, make up lipopeptide detergents (LPDs).
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