Question

For a weak acid with a pka = 6.5, the effective buffering range is usually considered to be ________.

Answer 1

The effective range of pH would be +/-10

6.5 + 10 = 7.5 or 6.5 - 10 = 5.5

What is effective buffering range ?

The effective pH range of a buffer is one pH unit on either side of the weak acid's pKa value. A buffer's ability to withstand significant pH variations will be lost if its pH falls outside of this range.

• All three aspects of the solution to be administered—pH, chemical make-up, and volume—must be taken into account. For the majority of pharmaceutical solutions, buffer capacities in the range of 0.01 to 0.1 are typically sufficient.

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