Protein tumor markers found both in normal fetal tissue and in certain tumors are referred to as oncofetal antigens.
Proteins hypothesised to be expressed at high levels in cancer cells and in fetal tissues but not in adult tissues were called oncofetal antigens.
The antigens are present in modest amounts even in normal adult tissues, indicating that their expression in adults is not just restricted to malignancies but also increases in tissues and in the circulation under diverse inflammatory situations.
Oncofetal antigens are chemicals that are produced by tumors as well as by foetal cells, however they are produced by adult tissues at much lower levels. There is a review of the recognized oncofetal antigens.
Proteins known as oncofetal antigens, which are generally only present during foetal development, are discovered in adults with specific types of cancer.
These proteins are frequently detectable in the blood of cancer patients and can be used for tumor diagnosis as well as tumor treatment monitoring.
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