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While a rodent's clinical examination is comparable to that of a bigger animal, it may be necessary to modify the techniques and tools employed due to the smaller size of the rodent.

One pair of continually growing incisors in the upper and lower jaws distinguishes rodents from other mammals in the order Rodentia. Rodents make up about 40% of all mammal species.

Rabbits are not considered members of the Rodentia since they have an extra set of incisors and other skeletal characteristics that set them apart from rodents. The Lagomorpha includes a few species of hares and rabbits. Rodents do not include hedgehogs, shrews, moles, or any other member of the Eulipotyphla order of mammals. Rodents only have two upper incisors, but rabbits have four (including two non-functional teeth). Rodents and bunnies both have two bottom incisors.

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