The first step of gluconeogenesis takes place within the mitochondrial matrix that involves the carboxylation of pyruvate.
The process of converting pyruvate into phosphoenolpyruvic acid is the initial step in the production of glucose (PEP). There are multiple stages and several enzymes needed to convert pyruvate to PEP. The three enzymes involved in this process are malate dehydrogenase, PEP carboxykinase, and pyruvate carboxylase.
Oxaloacetate is produced in the mitochondria by the carboxylation of pyruvate, which triggers the start of glucose synthesis. Pyruvate carboxylase is responsible for catalyzing this reaction, which also calls for one molecule of ATP.
The mitochondrial matrix hosts the initial stage of gluconeogenesis. Pyruvate carboxylase is an enzyme that connects ATP's exergonic hydrolysis to the pyruvate's endergonic carboxylation into the intermediate oxaloacetate.
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