Mainly Osteoarthritis (OA) happens when the joint-associated problems that can occur as normal changes to the articular cartilage as an individual ages.
It is a classic age-related disorder. It is often described as a chronic degenerative disease and thought by many to be an inevitable consequence of growing old. Cartilage is a firm, slippery tissue that enables nearly frictionless joint motion. Eventually, if the cartilage wears down completely, bone will rub on bone. In OA, degradation and loss of the articular cartilage is a central feature that is sometimes attributed to "wear and tear".
Beside Osteoarthritis, fibrillation of the articular surface, decrease in the size and aggregation of proteoglycan aggrecans, increased collagen cross-linking and loss of tensile strength and stiffness happens.
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