A translocation between chromosomes 8 and 14 results in an enhancer element in direct control on the c myc gene if the enhancer element leads to over expression this mutation is called intrachromosomal translocation.
The B-cell cancers Burkitt's lymphoma and acute lymphoblastic leukaemia(ALL) are characterised by the reciprocal chromosome translocation, or t(8;14), which involves the heavy chain locus on chromosome 14 and the c-myc oncogene on chromosome 8.
The intrachromosomal translocation connecting one c-myc allele to one of the immunoglobulin genes causes the dysregulation of c-myc gene expression in Burkitt's lymphoma. This physical connection encourages interactions between immunoglobulin and c-myc gene regulatory regions, which have an impact on the commencement and elongation of c-myc transcription.
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