Question

Acetophenone was treated by one equivalent of lda, followed by one equivalent of \it{tert}-butyl bromide. what are the most likely reaction products?

Answer 1

The most likely reaction product when acetophenone was treated by one equivalent of LDA, followed by one equivalent of tert-butyl bromide.

The full form of LDA is the lithium diisopropyle amide. The enolates can acts as nucleophile in SN2 type reaction . Overall an alpha hydrogen is replaced with an alkyl group . This reaction is one of the more important for enolates because a carbon - carbon bond formed .

Example :  when acetophenone was treated by one equivalent of LDA, which is base and abstract alpha hydrogen followed by one equivalent of tert-butyl bromide which gives tert-butyl bromide which is alkyl and such reaction is called alkylation.

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