In the early embryo DKK, Crescent, Cerberus, FGF8, and BMP signals must occur together in the splanchnic mesoderm for cardiogenic mesoderm to be specified.
Through BMP and FGF signalling pathways, the underlying anterior endoderm specifies the cardiogenic mesoderm layer. The two cell groups are instructed by these signals to differentiate separately as they move anteriorly toward the gut tube.
The infolding of a surface layer known as the splanchnic (or ventral) mesoderm brings the two endocardial tubes together, where they merge. Recent research reveals that endogenous Wnt inhibitors such the Sfrp and DKK proteins are crucial in controlling the differentiation of cardiomyocytes.
Therefore, In the early embryo DKK, Crescent, Cerberus, FGF8, and BMP signals must occur together in the splanchnic mesoderm for cardiogenic mesoderm to be specified.
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