Why do nonsense mutations tend to impact the final protein product more than missense mutations?

Nonsense mutations tend to impact the final protein product more than missense mutations because they produce shorter proteins due to the precense of the premature stop codon.

What are the types of point mutations?

Although, in some cases, mutations make the resulting proteins more efficient, usually, they make them less efficient than they should be.

In those cases in which the mutations turn to be beneficial for the protein function, it is favored by natural selection, and it fixates. This is what leads to evolution.

If the mutation is not favorable, it just gets lost.

When a change occurs in a single base pair, it is known as a point mutation.

Points mutations might be either silent, missense, or nonsense.

In silent mutations, the resulting mRNA codon codes for the same amino acid as the unmutated sequence.

However, if the mutation causes the mRNA codon to code for a different amino acid, this mutation is a missense mutation.

Finally, if the mutation causes mRNA codon to be a premature stop codon, we are referring to a nonsense mutation.

Missense mutations might alter the protein's function or not, depending on the mutation site and on wheather if the mutated amino acid is near or not to the active site. However, the protein length is the same.

Nonsense mutations change the original codon for a premature stop codon that should not be there. Hence, the protein will be shorter and there are higher chances of altering its functions.

Nonsense mutations tend to impact the final protein product more than missense mutations because they produce shorter proteins due to the precense of the premature stop codon.

You can learn more about point mutations at

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