Several Indian tribes who interacted with Europeans were wiped out by diseases brought by the Europeans. While Europe was in the early days of the Renaissance, there were empires in the Americas sustaining more than 60 million people.
The first European contact in 1492 brought diseases to the Americas which devastated the native population, and the resultant collapse of farming in the Americas was so significant that it may have even cooled the global climate. The time of the arrival of Europeans, the indigenous population was estimated to be just below 40 million people.
After the contact with European diseases it is said to be significantly reduced and estimates suggest that in 1650 this population could be around 8-9 million people.
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