What would occur if a lipid-insoluble ca2 channel antagonist was applied to cardiac contractile cells?
Independent of electrical stimulation, a2+ would enter the cell and encourage Ca2+ release from the SR to cause more frequent heart muscle contractions.
The majority (99 percent) of the cells in the atria and ventricles are cardiac contractile cells. During contractions that pump blood throughout the body, contractile cells carry out impulses. The conduction system of the heart is made up of myocardial conducting cells, which make up 1% of all cells. They are typically much smaller than contractile cells, with the exception of Purkinje cells, and contain significantly less myofibrils or filaments than contractile cells. Despite being specialized muscle cells, they perform many of the same tasks as neurons. The electrical impulse known as an action potential, which travels throughout the heart and causes cardiac contractions that move blood forward, is started and spread by myocardial conduction cells.
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