Condensation of nucleoside triphosphate with a hexose 1 phosphate to form a sugar nucleotide has a small free energy change and this condensation is irreversible because the reaction releases PPi, which is rapidly hydrolyzed by inorganic pyrophosphatase (highly exergonic).
PPi is kept low, making first step favorable & ensures results favorable energy change (exergonic) therefore formation of sugar nucleotides drives the reaction forward / is metabolically irreversible.
Reaction is strongly exergonic, due to coupling with hydrolysis of pyrophosphate (rapid removal of product shifts equilibrium forward to make reaction favorable).
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