When a person with a physiological dependence on a substance needs higher and higher doses to achieve a high, that person is experiencing the characteristic signs of tolerance.
When a substance is abused over an extended length of time, drug tolerance develops. When a person abuses a substance over time, their body adapts to it and the drug loses part of its potency. To maintain the same effects after developing a tolerance to an addictive drug, a person will start consuming bigger doses. High dosages of a chemical might have a lot of harmful effects.
The brain can suffer harm from prolonged drug usage that results in tolerance, dependence, or addiction. The sending, receiving, and processing of signals by neurotransmitters in the brain will be disrupted by long-term drug addiction. The abuse can have an impact on a person's actions as well as their capacity for rapid, clear thinking.
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