Diisopropylfluorophosphate (DPF) is the irreversible inhibitor (drug) used as an example in the lecture. the its an enzyme hydrolyses the pheophrous- Florine bond, but the phosphate remains bound to serine in the active site and deactivating it.
Irreversible inhibitor are contently /non contently bound to the specific enzyme and slow down the enzyme. invisible hibitors are 3 types such as group specific reagents , reactive substrate analogs also known as affinity label and inhibitor.
There are some examples of irreversible inhibitors -compound diisopropylphosphofluoridate (DIPF), nerve gases ,acetylcholinesterase ,and preventing transmission of impulse. Penicillin irreversibly inhibits the enzyme transpeptidase by reacting with transpeptidase.
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