Calcium that enters the cell during smooth muscle excitation binds with calmodulin.
What is calmodulin?
- All eukaryotic cells express calmodulin, a multifunctional intermediate messenger protein that binds calcium.
- Calmodulin is an intracellular target of the secondary messenger Ca2+, and Ca2+ binding is necessary for calmodulin activation.
- Various calcium-sensitive enzymes, ion channels, and other proteins get signals from calmodulin, a protein that functions as an intermediate protein that senses calcium levels.
- All eukaryotic cells have the calcium-binding protein calmodulin, also known as calcium-modulated protein, in their cytoplasm.
- It interacts with a large number of other proteins in the cell and performs a wide range of biological tasks as a regulator or effector molecule.
- Calmodulin binds calcium and magnesium.
- Different calcium-calmodulin complexes then bind to and activate enzymes that control cellular calcium or cyclic nucleotides as well as particular protein kinases that control target enzymes by ATP-dependent phosphorylation.
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