- Acid anhydride to ester conversion is called Alcoholyisis.
- Alcohols and anhydrides react to produce esters as the main product and a carboxylate as a byproduct.
- The reaction is often conducted with a base, such as NaOH or pyridine, to eliminate any acid generated.
- The ester contains one acyl group from the anhydride, and the carboxylate is formed by the other acyl group.
How acid anhydride is prepared?
- Acid chlorides and carboxylic acid or carboxylate anion are typically combined in a nucleophilic acyl substitution process to produce acid anhydrides.
- Anhydrides experience many of the same reactions as acid chlorides and are very reactive to nucleophilic assault.
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