[tex]PI3K,[/tex] the mechanism does [tex]pi-3[/tex] phosphate promote activation of pkb .
Normally, the regulatory subunit linked to the active receptor directly stimulates [tex]PI3K[/tex]or is indirectly stimulated by adaptor molecules such as the insulin receptor substrate (IRS) proteins. A RAS protein that binds to GTP can also activate [tex]PI3K[/tex].
A receptor tyrosine kinase (RTK) on the plasma membrane is triggered when an external ligand binds to it, producing receptor dimerization and cross-phosphorylation of tyrosine residues in the intracellular domains. Cell metabolism, growth, proliferation, and survival are all influenced by protein kinase B, also known as Akt. Phosphoinositide-3-kinase is a key player in a multi-step process that regulates its activation.
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